Development and characterization of cold-adapted viruses for use as live virus vaccines
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چکیده
منابع مشابه
Development and characterization of cold-adapted viruses for use as live virus vaccines.
Representative viruses from twelve RNA and two DNA virus genera have been successfully adapted to growth at sub-optimal temperature (cold-adapted). In almost every case, there was a correlation between acquisition of the cold-adaptation phenotype and loss of virulence in the normal host whether animal or man. Overall, the best method of cold adaptation to develop a live virus vaccine line appea...
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ژورنال
عنوان ژورنال: Vaccine
سال: 1985
ISSN: 0264-410X
DOI: 10.1016/0264-410x(85)90124-0